874: Overexpression of YAP rescue maternal diabetes induced neural tube defects
نویسندگان
چکیده
منابع مشابه
Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects.
Diabetes mellitus in early pregnancy increases the risk in infants of birth defects, such as neural tube defects (NTDs), known as diabetic embryopathy. NTDs are associated with hyperglycemia-induced protein misfolding and Caspase-8-induced programmed cell death. The present study shows that misfolded proteins are ubiquitinylated, suggesting that ubiquitin-proteasomal degradation is impaired. Mi...
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Preexisting maternal diabetes increases the risk of neural tube defects (NTDs). The mechanism underlying maternal diabetes-induced NTDs is not totally defined, and its prevention remains a challenge. Autophagy, an intracellular process to degrade dysfunction protein and damaged cellular organelles, regulates cell proliferation, differentiation, and apoptosis. Because autophagy impairment causes...
متن کاملNeural Tube Defects: A Review on Maternal Genetic Determinants
Neural Tube Defects, resulting from the failure in the closure of the neural tube, have been found to be one of the major causes of mortality and morbidity in the infants and have a variable worldwide incidence rate. Various debatable theories suggest different models for the process of the formation of the neural tube or neurulation, resulting in different types of NTDs. NTDs are an outcome of...
متن کاملMaternal smoking, body mass index, and neural tube defects.
The Swedish health registries were used to investigate a possible effect on the incidence of neural tube defects (NTDs) of maternal smoking and maternal body mass index (BMI) (kg/m2). Among 1,199,701 infants born in 1983-1993 with known smoking exposure in early pregnancy, 621 infants with NTDs were selected. After controlling for year of birth, maternal age, parity, education level, BMI, and i...
متن کاملNeural tube defects
lower limbs and other major organ malformations.4 Complex dysraphic states due to aberrant integration of the notochord include split cord malformation (SCM) or diastematomyelia: a congenital spinal anomaly in which there is longitudinal splitting of the spinal cord.5,6 Causes of NTDs are multifactorial and defects in several different genes can underlie the genetic basis of this disease.1 Howe...
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ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2020
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2019.11.887